How Ostizeel™ Works

A Targeted, Multi-Pathway Approach to Osteoarthritis Management

Osteoarthritis is a complex, progressive condition driven by chronic inflammation, nerve sensitization, and cartilage degradation. Ostizeel™ addresses this complexity through a scientifically designed, stepwise mechanism of action that targets pain at its source while supporting long-term joint function.

The infographic below visually explains how Ostizeel™ acts at multiple levels to deliver clinically meaningful results beginning with inflammation control and extending to muscle strengthening and cartilage preservation.

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Mechanism Overview
1. Osteoarthritis Risk Factors

Age, mechanical stress, obesity, genetics, and injury increase the risk of joint tissue breakdown, inflammation, and chronic pain.

2. Ostizeel™ Inhibits Inflammatory Mediator Release

The formulation acts on early-stage OA inflammation by regulating the release of pro-inflammatory cytokines such as TNF-α, IL-6, and IL-1β reducing tissue damage at the source.

3. Multi-Targeted Action Pathways

Ostizeel™ simultaneously targets three critical components of OA pathology:

  • Inhibits Nociceptive Pain Pathway Activation
    Modulates peripheral pain receptors triggered by joint tissue damage and inflammation.

  • Inhibits Neuropathic Pathway Activation
    Reduces neural sensitization and neuroinflammation through interaction with mast cells, TRPV1 receptors, PPAR-α, and microglial cells.

  • Strengthens Peri-articular Muscle
    Enhances muscle strength and function surrounding the affected joint, supporting mechanical stability and mobility.

4. Reduces Pain, Inflammation & Cartilage Breakdown

By acting on multiple mechanisms, Ostizeel™ helps relieve pain, improve flexibility, and inhibit matrix metalloproteinases (MMPs)  the enzymes responsible for cartilage degradation.

5. Controls Osteoarthritis Progression

With its disease-modifying potential, Ostizeel™ supports long-term joint integrity, helping delay the progression of OA and improving overall quality of life.

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