Ostizeel™ is a clinically formulated joint health supplement designed to reduce pain, control inflammation, and support cartilage protection through a science-backed, multi-pathway mechanism.
Clinical Evidence
Proven Efficacy Through Scientific Validation
Multi-Parameter Clinical Evaluation
Ostizeel™ has been clinically evaluated through multiple research studies to establish its effectiveness in addressing the multifactorial nature of osteoarthritis (OA). The formulation is designed to improve joint function, relieve pain, reduce inflammation, and protect cartilage integrity by targeting both nociceptive and neuropathic pathways.
Osteoarthritis is not a single-symptom disorder. It affects structural, neurological, and functional aspects of joint health. Ostizeel™ was assessed using standard global clinical evaluation tools, ensuring comprehensive measurement of its impact across multiple domains: WOMAC Score. VAS Score. LFI Score.
Pain Reduction
Significant reduction in joint pain was observed starting from Day 3, sustained over the treatment duration.
Enhanced Mobility
Increased joint range of motion, especially in knee flexion at 60°/s and 90°/s, reflecting improved mechanical function.
Cartilage Protection
Marked inhibition of cartilage-degrading enzymes (MMPs), leading to better joint structure preservation.
Improvement in joint health
WOMAC TOTAL Score
WOMAC Total Score
50
40
30
20
10
0
Baseline
Week 4
Week 8
WOMAC Stiffness Score
WOMAC Stiffness Score
5
4.5
4
3.5
3
2.5
2
1.5
1
0.5
0
Baseline
Week 4
Week 8
WOMAC Function Score
WOMAC Function Score
35
30
25
20
15
10
5
0
Baseline
Week 4
Week 8
WOMAC Pain Score
Cucumber extract
Placebo
Week 0
Week 8
Reduction in MMP-3
Reduction in MMP-3 (ng/mL)
14
12
10
8
6
4
2
0
*p=0.018
Reduction in IL-1β
% Reduction in IL-1β (pg/mL)
30
25
20
15
10
5
0
-5
-10
-15
-20
*p=0.004
Improvement in At 90° knee position
% Change compared to Placebo
Average power (W)
Relative peak torque (Nm/Kg)
Peak torque (Nm)
0
5
10
15
20
Safe. Effective. Clinically Verified.
The clinical benefits of Ostizeel™ go beyond pain relief — offering disease-modifying potential and long-term joint care. The consistent improvements observed across pain, stiffness, mobility, and inflammation parameters confirm its place as a next-generation solution in osteoarthritis management.
Multi-Targeted Joint Health Innovation
+91 8818817919
partnership@makinlaboratories.com, exportpartnership@makinlaboratories.com
33, Narmada Nagar, Annapurna Road, Indore, Madhya Pradesh – 452009