Ostizeel™ is a clinically formulated joint health supplement designed to reduce pain, control inflammation, and support cartilage protection through a science-backed, multi-pathway mechanism.
Integrated Cartilage Protection, Pain Control through Nociceptive and Neural Pathways
Advanced Joint Health Support Backed by Science.
Our Approach
A clinically validated formulation targeting pain, inflammation, and cartilage degradation through integrated action on nociceptive and neuropathic pathways.
Ostizeel™ is a next-generation nutraceutical formulation designed for the comprehensive management of osteoarthritis. It combines the scientifically validated power of Palmitoylethanolamide (PEA) and Cucumis sativus extract, working synergistically to target both nociceptive and neuropathic pain pathways.
This dual-action approach delivers fast-acting relief starting from Day 3, while also addressing deeper pathological mechanisms responsible for joint inflammation, degeneration, and stiffness.
Dual Pathway Pain Modulation
Targets both nociceptive and neuropathic components of osteoarthritis for comprehensive and sustained pain relief.
Supports Muscle Strength Around Joints
Enhances peri-articular muscle function, improving joint stability and reducing stress on damaged cartilage.
Acts on Novel Molecular Targets
Interacts with mast cells, TRPV1, PPAR-α, and microglial cells to interrupt pain and inflammation at the root.
Ostizeel™ delivers more than just pain relief
A clinical-grade solution that addresses the root causes of joint damage and offers sustainable mobility support.
Downregulates Inflammatory Biomarkers
Reduces levels of TNF-α, IL-6, NF-κB, and IL-1β, offering biological control over chronic inflammation.
Clinically Validated Outcomes
Proven efficacy in clinical trials using standard osteoarthritis metrics: WOMAC, VAS & LFI scores.
Improves Joint Function Performance
Promotes increased knee flexion strength and overall range of motion through muscle and structural support.
Superior to Conventional OA Therapies
Demonstrates better clinical outcomes compared to standard Disease-Modifying Anti-Osteoarthritis Drugs (DMOADs).
Protects and Preserves Cartilage
Inhibits matrix metalloproteinases (MMPs), preventing cartilage breakdown and supporting long-term joint integrity.
Synergistic Ingredient Composition
Combines Palmitoylethanolamide and Cucumis sativus extract for a potent, multi-targeted approach to OA care.
Research- Driven Innovation in Osteoarthritis Management
Ostizeel™ is built on robust scientific research targeting the complex pain and cartilage degradation pathways of osteoarthritis.
Multifactorial Pain Modulation
Ostizeel™ targets nociceptive and neuropathic pain by modulating mast cells, TRPV1, PPAR-α, and microglial cells, effectively interrupting pain transmission and neuroinflammation for comprehensive osteoarthritis relief.
Cartilage Preservation & Inflammation Control
The formulation inhibits matrix metalloproteinases (MMPs) and downregulates TNF-α, IL-6, NF-κB, and IL-1β, preserving cartilage integrity while reducing inflammation and slowing OA disease progression.
Multi-Targeted Joint Health Innovation
+91 8818817919
partnership@makinlaboratories.com, exportpartnership@makinlaboratories.com
33, Narmada Nagar, Annapurna Road, Indore, Madhya Pradesh – 452009